Toronto police say court officers were passing by at Morningside Avenue and found a two-vehicle collision, including one on fire.
They were able to pull a man out of the burning vehicle, while another had been ejected in the crash.
Four people were taken to hospital with injuries ranging from minor to serious, but non-life-threatening.
The driver was taken into custody for impaired driving, but no charges have been laid yet.
The off-ramp was been closed for repairs.